교수진

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교수

교수정보의 상세 화면
김은하
이름
김은하
학력
박사
전공
응용화학생명공학전공(과)
정보
연구실 :
팔달관 530

연구실번호 :
2460

이메일 :
ehkim01@ajou.ac.kr

연구관심분야 :

홈페이지 :
http://eunhakim.wix.com/ajou
학력
졸업연도/학교/학위
2011.08 서울대학교 박사
졸업연도/학교/학위
2005.02 서울대학교 학사
경력 2015.09 - current   Assistant Professor - Ajou University
2012.05 - 2015.08 Post doctoral Fellow - Harvard Medical School / Massachusetts General Hospital
2011.09 - 2012.04 Post doctoral Fellow - Seoul National University


연구분야 형광물질 물성 연구, 바이오 이미징, 분자 진단, 화학생물학
논문 및 연구활동
연구활동(주요논문)
  • [논문] 김은하, 성준, 노준기, 전경국, 민준식, Sanghee Lee, 김종현, 김욱, 추연정, A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity , BIOCONJUGATE CHEMISTRY , Vol.30 , No.1 , pp.210 -217 (Jan, 2019)
  • [논문] 김은하, 박승범, 조완상, 성준, 이영준, Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , pp.974 -983 (Jan, 2018)
  • [논문] 김은하, Katherine Yang, Ralph Weissleder, Randy J Giedt, Labros G Meimetis, Claudio Vinegoni, J Matthew Dubach, Michael Cuccarese, Quantitating drug-target engagement in single cells in vitro and in vivo , NATURE CHEMICAL BIOLOGY , pp.1 -9 (Dec, 2016)
  • [논문] 김은하, 이상희, 박승범, 이영준, Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor , ACCOUNTS OF CHEMICAL RESEARCH , Vol.48 , No.3 , pp.538 -547 (Mar, 2015)
  • [논문] 김은하, Ashley M. Laughney, Melissa M. Sprachman, Miles A. Miller1, Ralph Weissleder, Katy S. Yang, James D. Orth, Timothy J. Mitchison, Rainer H. Kohler, Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin , SCIENCE TRANSLATIONAL MEDICINE , Vol.6 , No.261 , pp.261ra152(1) -261ra152(11) (Nov, 2014)
국제학술논문지
  • [논문] 김은하, 구희범, Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo , CHEMICAL SCIENCE , pp.7835 -7851 (Sep, 2019)
  • [논문] 김은하, 성준, 노준기, 전경국, 민준식, Sanghee Lee, 김종현, 김욱, 추연정, A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity , BIOCONJUGATE CHEMISTRY , Vol.30 , No.1 , pp.210 -217 (Jan, 2019)
  • [논문] 장혜영, 임웅빈, 윤우진, 손성욱, 윤호섭, 김은하, 채수경, 임유나, 박지용, Template‐free anion‐controlled synthesis of Pd (II) nano‐aggregates for the antifouling polymerization of CO and ethylene , APPLIED ORGANOMETALLIC CHEMISTRY , Vol.33 , No.3 (Jan, 2019)
  • [논문] 김은하, 성준, 이상희, 박승범, 이효원, 박종민, 김환명, 조아라, 남현성, Near infrared fluorescent tracer for glucose uptake monitoring in live cell , BIOCONJUGATE CHEMISTRY , pp.3394 -3401 (Oct, 2018)
  • [논문] 김은하, 박승범, 조완상, 성준, 이영준, Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , pp.974 -983 (Jan, 2018)
  • [논문] 김은하, Kyle Frase, Bassel Ghaddar, Ralph Weissleder, Leonora Balaj, E. Antonio Chiocca, Xandra O. Breakfield, 이학호, 이경헌, Katy Yang, Multiplexed Profiling of Single Extracellular Vesicles , ACS NANO , Vol.12 , No.1 , pp.494 -503 (Jan, 2018)
  • [논문] 김은하, Miles A. Miller, Michael F. Cuccarese, Ralph Weissleder, Mark Prytyskach, Rainer H. Kohler, Mikael J. Pittet, Alec L. Plotkin, Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease , CHEMICAL COMMUNICATIONS , Vol.54 , No.1 , pp.42 -45 (Dec, 2017)
  • [논문] 김은하, 박승범, 차정현, 성준, 이영준, Development of fluorescent mitochondria probe based on 1,2-dihydropyrrolo[3,4-b]indolizine-3-one , DYES AND PIGMENTS , pp.461 -468 (Oct, 2017)
  • [논문] 김은하, 박종민, 강경태, Tetrazine ligation for chemical proteomics , PROTEOME SCIENCE , Vol.15 , No.15 , pp.1 -13 (Jun, 2017)
  • [논문] 김은하, 김훈기, 강경태, 김영관, 장홍재, Neuron-Material Nanointerfaces: Surface Nanotopography Governs Neuronal Differentiation and Development , CHEMNANOMAT , Vol.3 , No.5 , pp.278 -287 (May, 2017)
  • [논문] 김은하, Katherine Yang, Ralph Weissleder, Randy J Giedt, Labros G Meimetis, Claudio Vinegoni, J Matthew Dubach, Michael Cuccarese, Quantitating drug-target engagement in single cells in vitro and in vivo , NATURE CHEMICAL BIOLOGY , pp.1 -9 (Dec, 2016)
  • [논문] 김은하, Replacement of Dialkyl Amino Group on D-A type Fluorophores to Increase the Brightness , BULLETIN OF THE KOREAN CHEMICAL SOCIETY , Vol.37 , No.11 , pp.1741 -1742 (Nov, 2016)
  • [논문] 김은하, 박용일, Chen-Han Huang, Ralph Weissleder, Cesar M. Castro, 이학호, 박기수, Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing , BIOCONJUGATE CHEMISTRY , pp.1 -5 (Oct, 2016)
  • [논문] 김은하, 박승범, 정진주, 조아라, A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics , CHEMICAL COMMUNICATIONS , pp.7433 -7445 (Jun, 2016)
  • [논문] 김은하, 구희범, 윤석현, 한세광, Ralph Weissleder, 최명환, Bioorthogonal Click Chemistry-Based Synthetic Cell Glue , SMALL , Vol.11 , No.48 , pp.6458 -6466 (Dec, 2015)
  • [논문] 김은하, Ralph Weissleder, John M. Dubach, Hannes Mikula, Katherine S. Yang, Rainer H. Kohler, Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression , BIOCONJUGATE CHEMISTRY , Vol.26 , No.8 , pp.1513 -1518 (Aug, 2015)
  • [논문] 김은하, Anna Turetsky, 이경헌, Jun Song, Ralph Weissleder, Alexandra E. Kovach, Ephraim P. Hochberg, Cesar M. Castro, 이학호, Randy J. Giedt, On chip analysis of CNS lymphoma in cerebrospinal fluid , THERANOSTICS , Vol.5 , No.8 , pp.796 -804 (Apr, 2015)
  • [논문] 김은하, 이상희, 박승범, 이영준, Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor , ACCOUNTS OF CHEMICAL RESEARCH , Vol.48 , No.3 , pp.538 -547 (Mar, 2015)
  • [논문] 김은하, Ashley M. Laughney, Melissa M. Sprachman, Miles A. Miller1, Ralph Weissleder, Katy S. Yang, James D. Orth, Timothy J. Mitchison, Rainer H. Kohler, Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin , SCIENCE TRANSLATIONAL MEDICINE , Vol.6 , No.261 , pp.261ra152(1) -261ra152(11) (Nov, 2014)
  • [논문] 김은하, Katherine S. Yang, Randy J. Giedt, Ralph Weissleder, Red Si?rhodamine drug conjugates enable imaging in GFP cells , CHEMICAL COMMUNICATIONS , Vol.50 , No.34 , pp.4504 -4507 (May, 2014)
  • [논문] 김은하, Ralph Weissleder, Miles A. Miller, Anna Turetsky, Rainer H. Kohler, Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor , SCIENTIFIC REPORTS , Vol.4 , pp.4782(1) -4782(7) (Apr, 2014)
  • [논문] 김은하, 최은정, 박승범, 조아라, 이영준, Rational Perturbation of the Fluorescence Quantum Yield in Emission-Tunable and Predictable Fluorophores (Seoul-Fluors) by a Facile Synthetic Method Involving C-H Activation , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , Vol.53 , No.5 , pp.1346 -1350 (Jan, 2014)
  • [논문] 김은하, Ralph Weissleder, Katherine S. Yang, Bioorthogonal small molecule imaging agents allow single-cell imaging of MET , PLoS ONE , Vol.8 , No.11 (Nov, 2013)
  • [논문] 김은하, 박승범, 이상희, Discovery of autophagy modulators through the construction of a high-content screening platform via monitoring of lipid droplets , CHEMICAL SCIENCE , Vol.4 , No.8 , pp.3282 -3287 (Aug, 2013)
  • [논문] 김은하, 배세원, 홍종인, 박승범, 신익수, Fluorescent chemosensor for biological zinc ions , SUPRAMOLECULAR CHEMISTRY , Vol.25 , No.1 , pp.2 -6 (Jan, 2013)
  • [논문] 김은하, 강효진, 박승범, Alvin R. Cho, 정상전, 정명선, 최은정, A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase?a dual-specific protein tyrosine phosphatase , CHEMICAL COMMUNICATIONS , Vol.48 , No.52 , pp.6553 -6555 (Jul, 2012)
  • [논문] 김은하, 강준희, 김성근, 설수환, 박승범, 양일승, 한혁수, Photochemical generation of a new, highly fluorescent compound from non-fluorescent resveratrol , CHEMICAL COMMUNICATIONS , Vol.48 , No.32 , pp.3839 -3841 (Apr, 2012)
  • [논문] 김은하, 박승범, 이상희, A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening , CHEMICAL COMMUNICATIONS , Vol.48 , No.17 , pp.2331 -2333 (Feb, 2012)
  • [논문] 김은하, 박승범, 이상희, 9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors , CHEMICAL COMMUNICATIONS , Vol.47 , No.27 , pp.7734 -7736 (Jul, 2011)
  • [논문] 김은하, 고민섭, 임병준, 박승범, Emission wavelength prediction of a full-color-tunable fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , Vol.133 , No.17 , pp.6642 -6649 (May, 2011)
  • [논문] 김은하, 박승범, Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths , CHEMISTRY-AN ASIAN JOURNAL , Vol.4 , No.11 , pp.1646 -1658 (Nov, 2009)
  • [논문] 김은하, 류지훈, 박승범, 고민섭, Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , Vol.130 , No.37 , pp.12206 -12207 (Sep, 2008)
  • [논문] 김은하, 박승범, 장환종, 고성곤, Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif , CHEMICAL COMMUNICATIONS , Vol.28 , No.28 , pp.2962 -2964 (Jul, 2006)
  • [논문] 김은하, 윤태종, 유경남, 김준성, 박승범, 윤상현, 손병혁, 조명행, 이진규, 김병걸, Specific targeting, cell sorting, and bioimaging with smart magnetic silica core-shell nanomaterials , SMALL , Vol.2 , No.2 , pp.209 -215 (Feb, 2006)
국제학술발표
  • [학술회의] 김은하, Fluorescent Pattern Generating Chemical Sensor Array: Volatile Organic Compounds Recognition Assisted by Machine Learning Algorithm , The 3rd A3 Roundtable Meeting on chemical Probe Research Hub (Nov, 2018)
  • [학술회의] 김은하, Development of Companion Imaging Probe for Intravital Imaging Techniques to Study Pharmacokinetics and Pharmacodynamics in vivo , 2018 Fall International Convention of The Pharmaceutical Society of Korea (Oct, 2018)
  • [학술회의] 김은하, 안정모, 김현기, 고정길, Volatile Organic Compounds Recognition Using a Smartphone Camera and Fluorometric Sensors , Workshop on Combining Physical and Data-driven Knowledge in Ubiquitous Computing 2018 , pp.1 -8 (Oct, 2018)
  • [학술회의] 김욱, 윤성화, 김은하, 김정은, 윤주환, Characterization of AJ5012 as a Novel Peripheral Cannabinoid 1 Receptor Antagonist in Mouse Models of Obesity , 78th Scientific Sessions of American Diabetes Association (Jun, 2018)
  • [학술회의] 김은하, Super-Dark Rainbow Fluorogenic Probes for inverse Electron Demand Diels-Alder Bioorthogonal Reaction , 2nd A3 Roundtable Meeting on Chemical Probe Research Hub (Nov, 2017)
  • [학술회의] 김은하, 최상기, 김현기, Investigation of structure-photophysical property relationship of indolizine for fine-tuning the emission wavelength to cover full RGB color , International Chemical Biology Society 2017 (Oct, 2017)
  • [학술회의] 김은하, 조아라, 박승범, 성준, Synthesis and characterization of new near-infrared fluorecent glucose tracer for monitoring glucose uptake level in liv cell , International Chemical Biology Society 2017 (Oct, 2017)
  • [학술회의] 김은하, Rational Molecular Design Strategy Allowed Super-Dark Rainbow Fluorogenic Probes for iEDDA Bioorthogonal Reaction , 2017 China-korea Young Professor Joint Symposium in Chemistry (Jul, 2017)
  • [학술회의] 김은하, 차정현, 성준, Development of fluorescent mitochondria probe based on 1,2-dihydro-3H-pyrrolop[3,4-b]indolizine-3-one , The 118th General Meeting of the Korean Chemical Soceity (Oct, 2016)
  • [학술회의] 김은하, 박승범, 이영준, Colorful Bioorthogonal Turn-on Probes with a Single Fluorescent Core Skeleton , The 118th General Meeting of the Korean Chemical Soceity (Oct, 2016)
  • [학술회의] 김은하, Development of Companion Imaging drug for In vivo study , The 1st Roundtable Meeting on Chemical Probe Research Hub, Fukuoka, Japan (Sep, 2016)
  • [학술회의] 김은하, Development of Companion Imaging Drug for Intravital Imaging , 2016 KSBB Spring Meeting and International Symposium (Apr, 2016)
국내학술발표
  • [학술회의] 김은하, 김현기, 최상기, Investigation of the aggregation induced emission (AIE) fluorescent dye Kaleidolizine , 2018 공업화학회 춘계 학술대회 (May, 2018)
  • [학술회의] 김은하, 신민철, Development of hypoxia detecting fluorescent probe based on understanding of structure-photophysical property relationship of Seoul-Fluor , 2018 공업화학회 춘계 학술대회 (May, 2018)
  • [학술회의] 김은하, 성준, A New Near Infrared mitochondria targeting bioprobe via control molecular hydrophobicity , 2018 공업화학회 춘계 학술대회 (May, 2018)
  • [학술회의] 김은하, 최상기, 김현기, Development and applications of 75 different fluorescent materials based on indolizine core skeleton , 2018 공업화학회 춘계 학술대회 (May, 2018)
  • [학술회의] 김은하, 최상기, 김현기, Photophysical properties of 75 different Kaleidoscopic Indolizines and Potential Application for VOC Recognition , 대한화학회 제121회 학술발표회 및 총회 (Apr, 2018)
  • [학술회의] 김은하, 신민철, Hypoxia detecting fluorescent probe using Seoul Fluor`s rational changing of fluorescent property at reducible condition , 대한화학회 제121회 학술발표회 및 총회 (Apr, 2018)
  • [학술회의] 김은하, 김현기, 최상기, The aggregation induced emission enhancement (AIEE) of Kaleidolizine , 대한화학회 제121회 학술발표회 및 총회 (Apr, 2018)
  • [학술회의] 김은하, 박승범, 이영준, Tetrazine-Containing Colorful Bioorthogonal Probes based on the Indolizine Core Skeleton , 대한화학회 제121회 학술발표회 및 총회 (Apr, 2018)
  • [학술회의] 김은하, 최상기, 김현기, Combinatorial approach unveils the structure-photophysical property relationship of indolizine fluorescent core skeleton: fluorescent pattern-generating sensor array for VOCs (Volatile Organic Compound) recognition , 2017 한국공업화학회 추계 학술대회 (Nov, 2017)
  • [학술회의] 김은하, 이영준, 박승범, 성준, A development of new hypoxia turn-on probe using 1,2-dihydropyrrolo[3,4-b]indolizine-3-one , 2017 한국공업화학회 추계 학술대회 (Nov, 2017)
  • [학술회의] 김은하, Fluorescent material for bioimaging in in vitro and in vivo , 2017 한국공업화학회 춘계학술대회 생체재료 세션 (May, 2017)
  • [학술회의] 김은하, 최상기, 김현기, Photophysical property study of C-1, C-3 and C-7 modified indolizine for versatile fluorescent material application , 2017 한국공업화학회 춘계학술대회 (May, 2017)
  • [학술회의] 김은하, 김윤영, 강경태, 성준, A New Near-IR glucose tracer for monitoring glucose uptake in primary neuronal cells , 2017 한국공업화학회 춘계학술대회 (May, 2017)
  • [학술회의] 김은하, Ralph Weissleder, 이효진, 강정민, 최상기, Bacteriophage-based Bacterial detection technology utilizing TCO/Tz bioorthogonal click chemistry , 2017 한국공업화학회 춘계학술대회 (May, 2017)
  • [학술회의] 김은하, Ralph Weissleder, 최상기, 강정민, 이효진, A Novel way to immobilize Bacteriophage onto a Detection Platform with a Click , 대한화학회 제 119회 총회 (Apr, 2017)
  • [학술회의] 김은하, 김현기, 최상기, Structural photophysical property relationship study about indolizine fluorescent core skeleton , 대한화학회 제 119회 총회 (Apr, 2017)
  • [학술회의] 김은하, 성준, 박승범, 조아라, Synthesis and characterization of new near-infrared fluorescent glucose tracer for glucose uptake monitoring in live cell condition , 대한화학회 제 119회 총회 (Apr, 2017)
저서 및 번역
  • [저서] 김은하, 조슬아, 서주영, 김종현, 응용화학생명공학 데이터분석 워크북 (Sep, 2018)
특허 및 기타
  • [특허] 김은하, 박승범, 이영준, 신민철, 하이드라진 검출용 신규 형광 프로브 및 이를 포함하는 하이드라진 검출용 조성물 (출원) (10-2019-0124718) (Oct, 2019)
  • [특허] 김은하, 이상희, 추연정, 미토콘드리아를 표적으로 하는 신규한 근적외선 형광 프로브 및 이를 포함하는 종양 진단 및 치료 겸용 조성물 (출원) (10-2019-0087085) (Jul, 2019)
  • [특허] 김은하, 청각증진을 위한 자가힐링 펩타이드 모티브를 포함하는 바이오 메디컬 소재 및 생체환경/외부자극에 의한 자가힐링 펩타이드 모티브의 능동형 방출 제어 방법 (출원) (10-2019-0066186) (Jun, 2019)
  • [특허] 최상돈, 김은하, 톨-유사 수용체 3/7/8/9 억제 기능이 있는 길항성 소분자 화합물 TAC5 시리즈 (출원) (PCT/KR2019/005978) (May, 2019)
  • [특허] 김은하, 이상희, 성준, 노준기, 김종현, 김욱, 소수성기가 도입된 실리콘-로다민 형광 프로브 및 이의 용도 (출원) (10-2019-0049788) (Apr, 2019)
  • [특허] 최상돈, 김은하, 톨-유사 수용체 3/7/8/9 억제 기능이 있는 길항성 소분자 화합물 TAC5 시리즈 (출원) (10-2018-0107638) (Sep, 2018)
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